They assessed pain again after the study to compare how Cymbalta and a placebo affected pain. Cymbalta is FDA-approved to treat fibromyalgia. This is a chronic condition that can cause:. Fibromyalgia is often misdiagnosed and can be difficult to treat. Clinical studies have shown Cymbalta to be effective at treating fibromyalgia.
One study compared Cymbalta with a placebo in adults with fibromyalgia. Before the study, these adults had an average pain score of 6. People in the study took either Cymbalta or a placebo every day for 6 months. The researchers then measured their pain scores again to see if there was any improvement.
Cymbalta is FDA-approved to treat chronic musculoskeletal pain. This refers to pain in the bones, muscles, ligaments, nerves, and tendons. Chronic pain is pain that lasts for more than 3 to 6 months. Clinical studies have shown Cymbalta to be effective for treating chronic musculoskeletal pain. These studies involved adults with chronic low back pain or chronic pain caused by osteoarthritis a joint disorder that causes swelling and pain. In one study , adults with chronic low back pain took either Cymbalta or a placebo every day for 13 weeks.
Before the study, people rated their pain on a scale of 0 no pain to 10 worst pain possible. The researchers had people rate their pain again at the end of the study. Clinical studies have shown Cymbalta to be effective for treating these conditions in children. Cymbalta belongs to a class of medications known as serotonin-norepinephrine reuptake inhibitors SNRIs. It affects your levels of both serotonin and norepinephrine.
SSRIs, on the other hand, only affect your serotonin levels. Controlled substances are medications that could cause either physical or mental dependence. With dependence , your body needs the drug to feel normal.
The Drug Enforcement Administration DEA sets limits on who can make, possess, and use medications that are controlled substances. However, Cymbalta could cause withdrawal symptoms if you stop taking the drug suddenly.
Addiction is different from dependence. Over time, someone with addiction needs more and more of a drug to feel its effects. This is because the drug affects your central nervous system CNS. If you have questions or concerns about your risk for dependence with Cymbalta, talk with your doctor. Cymbalta is approved to treat mood disorders, such as depression and anxiety. Because it affects your mood, some people report feeling calm or as if their mood is boosted while taking the drug.
If you have questions about how Cymbalta may affect you, talk with your doctor or pharmacist. This was one of the more common side effects of the drug in clinical studies. In the studies:. If you have questions about side effects from Cymbalta, talk with your doctor or pharmacist. You may wonder how Cymbalta compares with other medications that are prescribed for similar uses.
Here we look at how Cymbalta and Lexapro are alike and different. Lexapro contains the active drug escitalopram. Lexapro belongs to a class of medications called selective serotonin reuptake inhibitors SSRIs. Both types of drugs are commonly used as antidepressants. Cymbalta comes as capsule that you take by mouth. Cymbalta and Lexapro have some similar side effects and others that vary. Below are examples of these side effects. This list contains 10 of the most common mild side effects that can occur with both Cymbalta and Lexapro when taken individually :.
These lists contain examples of serious side effects that can occur with Cymbalta, with Lexapro, or with both drugs when taken individually. The use of Cymbalta and Lexapro in treating depression in adults has been compared in a meta-analysis. A meta-analysis is a type of study that looks at the results of numerous clinical studies to see if there are any consistent results across the studies.
In this meta-analysis , researchers looked at 16 different clinical studies that compared Cymbalta to other antidepressants, including three studies that compared Cymbalta with Lexapro.
The researchers found the two drugs to be similarly effective for treating depression. Cymbalta and Lexapro have also been compared in a meta-analysis for treating anxiety in adults.
The researchers looked at 41 clinical studies involving a total of 11 antidepressants, including Cymbalta and Lexapro. They found Cymbalta and Lexapro to be similarly effective for treating anxiety.
According to estimates on GoodRx. Lexapro is available as a generic drug called escitalopram. Cymbalta and Effexor XR are prescribed for similar uses. Here we look at how these drugs are alike and different. Effexor XR contains the active drug venlafaxine ER. Duloxetine and venlafaxine ER both belong to a class of medications known as serotonin-norepinephrine reuptake inhibitors SNRIs. This medication class is commonly used as antidepressants.
Cymbalta and Effexor have some similar side effects and others that differ. This list contains 10 of the most common mild side effects that can occur with both Cymbalta and Effexor XR when taken individually :. These lists contain examples of serious side effects that can occur with Cymbalta, with Effexor XR, or with both drugs when taken individually.
The use of Cymbalta and Effexor XR in treating depression in adults has been compared in a meta-analysis. In this meta-analysis , researchers looked at 16 clinical studies comparing Cymbalta with other antidepressants , including three studies that compared Cymbalta with Effexor XR. A clinical study directly compared Cymbalta and Effexor XR for treating anxiety in adults. In this study, the researchers randomly assigned people to take either Cymbalta, Effexor XR, or a placebo a treatment with no active drug once a day for 10 weeks.
At the end of the study, the researchers found that people who took Cymbalta or Effexor XR had improved HAM-A scores compared with those who took a placebo. They found Cymbalta and Effexor XR to be similarly effective for treating anxiety. Effexor XR is available as a generic drug called venlafaxine ER. Other drugs are available that can treat your condition. Some may be a better fit for you than others. They can tell you about other medications that may work well for you.
Note: Some of the drugs listed here are used off-label to treat these specific conditions. Examples of other drugs that may be used to treat depression include:.
Examples of other drugs that may be used to treat anxiety include:. Examples of other drugs that may be used to treat diabetic neuropathy diabetic nerve pain include:. Examples of other drugs that may be used to treat fibromyalgia include:. Examples of other drugs that may be used to treat chronic musculoskeletal pain pain in the bones, muscles, ligaments, nerves, and tendons include:.
On its own, Cymbalta has caused liver damage and liver failure. In rare cases, this liver damage was fatal. Therefore, drinking heavily during your Cymbalta treatment could raise your risk for liver damage even more. If you drink alcohol, talk with your doctor before you start taking Cymbalta. Depending on the amount of alcohol you consume, they may decide to have you try a different medication for your condition.
Cymbalta belongs to a drug class called serotonin-norepinephrine reuptake inhibitors SNRIs. Cymbalta begins working as soon as you take your dose. It takes about 3 days for levels of the drug to become stable in your body. For example, in clinical trials , some adults with pain caused by diabetic neuropathy nerve damage , as well as some adults with fibromyalgia, noticed improvement within 1 week of starting the drug.
However, the National Alliance on Mental Illness notes that full improvement of depression symptoms may take up to 8 weeks. If you have questions about how Cymbalta works, or how long it takes to work, talk with your doctor or pharmacist. Cymbalta can interact with several other medications. It can also interact with certain supplements. Different interactions can cause different effects.
Secondary measures included effects on associated pain and functioning. Pain was assessed using a Visual Analogue Scale. Approximately four million Americans are diagnosed with generalized anxiety disorder each year.
The illness also tends to be chronic with periods of exacerbation and remission. Serotonin and norepinephrine in the brain and spinal cord are believed to both mediate core depression symptoms and help regulate the perception of pain. It is common for anxiety disorders to be associated with other disorders, such as depression. Based on pre- clinical studies, duloxetine is a balanced and potent reuptake inhibitor of serotonin and norepinephrine.
While the mechanism of action of duloxetine is not fully known, scientists believe its effect on both emotional symptoms and pain perception is due to increasing the activity of serotonin and norepinephrine in the central nervous system. Cymbalta is approved in the United States for the treatment of major depressive disorder and the management of diabetic peripheral neuropathic pain, both in adults.
Cymbalta is not approved for use in pediatric patients. In clinical studies, antidepressants increased the risk of suicidal thinking and behavior in children and adolescents with depression and other psychiatric disorders.
Anyone considering the use of Cymbalta or any other antidepressant in a child or adolescent must balance the risk with the clinical need. Patients who are starting therapy should be observed closely for worsening depression symptoms, suicidal thoughts or behavior, or unusual changes in behavior.
Headache, nausea, diarrhea, dry mouth, decreased appetite, increased sweating, feeling nervous, restless, fatigued, sleepy or having trouble sleeping insomnia. These will often improve over the first week or two as you continue to take the medication.
Sexual side effects, such as problems with orgasm or ejaculatory delay, and blood pressure increases often do not improve over time. There have been rare reports of liver failure sometimes fatal with duloxetine. This risk is increased in those with substantial alcohol use or chronic liver disease. Orthostatic hypotension, or a drop in blood pressure when standing or getting up from sleeping, has been reported in patients taking duloxetine.
The risk may be greater in patients also taking medications for high blood pressure. Increased heart rate, irregular menstrual cycle, increased frequency of urination or difficulty urinating, increased liver enzymes, teeth grinding, low sodium symptoms of low sodium levels may include headache, weakness, difficulty concentrating and remembering , angle closure glaucoma symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye , serotonin syndrome symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death , hypertensive crisis severely elevated blood pressure , myocardial infarction heart attack , Stevens-Johnson Syndrome rash , pancreatitis SNRI antidepressants, including duloxetine, may increase the risk of bleeding events.
Combined use of aspirin, nonsteroidal anti-inflammatory drugs e. This may include gums that bleed more easily, nose bleed, or gastrointestinal bleeding. Some cases have been life threatening. To date, there are no known problems associated with long term use of duloxetine.
It is a safe and effective medication when used as directed. Duloxetine should not be taken with or within 2 weeks of taking monoamine oxidase inhibitors MAOIs. Sleep, energy, or appetite may show some improvement within the first weeks. Improvement in these physical symptoms can be an important early signal that the medication is working.
Depressed mood and lack of interest in activities may need up to weeks to fully improve. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs. In short-term studies, antidepressants increased the risk of suicidality in children, adolescents, and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age Adults age 65 and older taking antidepressants have a decreased risk of suicidality.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. All patients being treated with antidepressants for any indication should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
Last Updated: January Urgent advice: Call your doctor straight away if you take too much duloxetine and:. Common side effects These side effects happen in more than 1 in people. These are not all the side effects of duloxetine.
For a full list, see the leaflet inside your medicines packet. Information: You can report any suspected side effect to the UK safety scheme. What to do about: difficulty sleeping - try taking duloxetine first thing in the morning headaches - make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if they last longer than a week or are severe. If you begin to feel dizzy, lie down so you do not faint, then sit until you feel better.
Do not drive or use tools or machines if you feel dizzy, have muscle cramps or muscle pain, or if you just feel a bit shaky. If it lasts for more than a day or two, speak to your doctor as they may need to change your treatment.
Try to exercise more regularly by going for a daily walk or run, for example. If this does not help, talk to your pharmacist or doctor.
Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor first. Make sure you take duloxetine in the morning with some food and try small, frequent sips of water if you're being sick to avoid dehydration.
If this does not help, you may need to try a different type of antidepressant. Try taking duloxetine 1 hour before bedtime. Cut down the amount of alcohol you drink as this will make you feel more tired. If this symptom does not go away after a week or two, ask your doctor for advice.
It may also help to eat smaller meals more often and eat foods you really enjoy. If your appetite does not improve or you lose a lot of weight, ask your doctor for advice. Duloxetine and breastfeeding If your doctor or health visitor says your baby is healthy, duloxetine may be used during breastfeeding.
Non-urgent advice: Tell your doctor if you're:. Tell your doctor if you're taking: any other medicines for depression - some rarely used antidepressants can interfere with duloxetine to cause very high blood pressure even after you have stopped taking them medication used to thin the blood, such as warfarin diazepam, chlorphenamine or other medication that can make you feel more sleepy tramadol — this can increase the chances of you having certain side effects Mixing duloxetine with herbal remedies and supplements Do not take the herbal remedy St John's wort while you're being treated with duloxetine, as this will increase your risk of side effects.
Important Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements. How does duloxetine work? When will I feel better? Give the medicine at least 6 weeks to work. How will it make me feel? You'll hopefully take things that used to worry you in your stride. How long will I take it for? How long you take it for depends on why you're taking it.
Is it safe to take it for a long time? Yes, duloxetine is safe to take for a long time.
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